- This topic has 4 replies, 5 voices, and was last updated 3 weeks, 1 day ago by
Margaret Sullivan.
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- December 3, 2025 at 9:53 pm
Q&A with Patti Columbe: Journey with Vertex’s manufactured isletsLearn more about clinical trials and how you can get involved. If you’re interested in the zimislecel clinical trial, check out the trial sites and eligibility criteria.
To accelerate T1D cures faster than ever, Breakthrough T1D’s Project ACT (Accelerate Cell Therapies) is simultaneously advancing research, development, regulatory policies, access, and adoption of manufactured islet therapies that do not require broad immunosuppression. We will not stop until these therapies are available to everyone with T1D who wants them—and clinical trial participants like Patti are getting us there faster.
We are well on our way to seeing manufactured cell therapies like zimislecel come to life. We owe a huge thank you to our supporters and the broader T1D community for inspiring us every day to keep pushing forward until functional cures for T1D are a reality.
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- December 4, 2025 at 8:46 pm
This is amazing Patti. So inspiring to read that Q&A. Thank you for stepping up to participate and moving us one step closer to a cure!- February 25, 2026 at 9:53 pm
Patti, this is awesome information. What a win for the T1D community!- February 26, 2026 at 1:04 pm
Following this exciting research and looking forward to hearing more about successful clinical trial outcomes!(My T1D daughter lives right across the river and got to see the Vertex building prominently sitting on the shore across the way!)
- March 16, 2026 at 11:58 am
It is so promising to see the advancements in Type 1 DM research. There is nothing easy about managing this disease. I was diagnosed at 24 years and at the time I was told “there will be a cure in your lifetime” so take care of yourself so you can benefit.Well I am 66 now and still no cure but we do have so many more tools for treatment! I have worked very hard to take care of myself and it has required constant attention.
I worked in Family Practice/and Internal Medicine practice as their Diabetes Education Specialist before retirement. I was excited to attend a program related to early screening for DM1 and the use of Teplizumab as a potential treatment for delaying onset.
I thought the information was something that should have been shared with the other physician’s and also was a great topic to share with the residents in the program. Their patient’s could have benefited. I was not able to get any agreement to share the information. There was no interest, surprisingly.
The screening is so exciting yet I am not sure I would have wanted to know I was likely to get DM1 before getting it. Being told I had it was the worst news I have ever received. Other’s may want to know and it is awesome that Teplizumab could possible delay onset, however it can not prevent at this time. Hopefully it won’t be long!
Tagged: Clinical Trials
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